Allergenic chemicals enter the body through certain pathways, combine with tissue proteins to form antigens, and stimulate immune-active cells to produce allergenic lymphocytes or humoral antibodies.
After 1-2 weeks of sensitization, the immune response in vivo is fully developed and a certain number of sensitized lymphocytes or specific antibodies are formed. When again exposed to the chemical, the body in a state of increased sensitivity, and to a certain abnormal form.
STANDARDS
ISO 10993-10，GB/T 16886.10，EN ISO 10993-10，GB/T 14233.2, YY/T 0268
Skin Sensitization Tests
Two guinea pig tests are currently used to determine the skin sensitization activity of chemicals and medical devices: Buehler test and GPMT. The two methods are composed of induction and excitation and involve the whole process of hypersensitivity reaction.
